PDGFRA and cancer: Dysregulation of PDGFR alpha (PDGFRα), one of receptors tyrosine kinase (RTK), has been reported in a broad range of cancer including glioblastoma, breast cancer, hepatocellular carcinomas, pancreatic cancer, and ovarian cancer [4, 7–9], either by protein overexpression or by the effect of mutations and chromosomal rearrangements.