Similar with this conclusion, Damavandi et al. demonstrated that the serum insulin and the LDL-C/HDL-C ratio lowered obviously in patients using PUFAs compared with the control individuals, indicating that consumption of PUFAs could lower circulating insulin and LDL-C/HDL-C ratio in patients with type 2 diabetes mellitus [59]. The gene discussed is INS; the disease is type 2 diabetes mellitus.