TNF and neoplasm: In the case of second AP-2 family representative, tumor versus normal tissue changes also affected processes (e.g. autophagy, adhesion, vesicle budding, extracellular matrix organization, apoptosis, cell growth and spreading) and signaling pathways (e.g. TNF, EGFR, Wnt, JAK-STAT, mTOR, NFkB and TGFβ) which is summarized in Fig. 9.