Through the treatment of MCAO model, it provides preliminary evidence for the pharmacological mechanism of Salvia combined with Safflower in the treatment of CI.Danhong compatibility group can significantly reduce the cerebral infarction rate, cerebral cell edema, glial cell proliferation, and inflammatory cell infiltration, increase the content of SOD and GSH, and reduce the content of MDA and NOS. Here, NOS2 is linked to brain infarction.