TNF and cancer: The top 20 most enriched pathways are listed in Table 2.Fluid shear stress and atherosclerosis, the AGE-RAGE signaling pathway in diabetic complications, the IL-17 signaling pathway, malaria, the HIF-1 signaling pathway, the TNF signaling pathway, toxoplasmosis, Kaposi sarcoma-associated herpesvirus infection, proteoglycans in cancer, and leishmaniasis were involved in the pathological development of MI and CI.