In this group of Chinese Han adults, the relationship between two airway epithelial-related genes EMSY and CDHR3 and risk of asthma were investigated, and four polymorphisms related to asthma susceptibility were obtained, which were rs3847076 of CDHR3 and rs2508746, rs1892953 and rs12278256 of EMSY. A further subgroup analysis of these four variants revealed that their association with asthma was present in different subgroups. Here, CDHR3 is linked to asthma.