In synthesis the use of Rib/Eve in concurrent therapy, compared to monotherapy with Rib or Eve alone or sequential therapy with Rib/Eve schedule or vice versa, results in several advantages: a) increases the pro-apoptotic effect compared to that of Rib alone b) decreases the levels of Rb phosphorylation and consequently augment the efficiency of treatment c) inhibits the Rib-induced senescence and avoids the BC stem-cells generation and apoptotic resistance d) avoids the Rib-induced resistance by reducing Rib dose and delays the initiation of chemotherapy. The gene discussed is RB1; the disease is breast cancer.