TOR1A and cranioectodermal dysplasia: Although HLA-DQ2 has a reduced ability to interact with co-factor DM compared to other class-II molecules [12], suggesting a deteriorated presentation of the antigen to T helper cells and this, in turn, could influence the antiviral response of DQ2 positive individuals, up to now there is very contrasting data on the presence of an altered immune response to viruses in CeD patients.