Here, we found that the expressions of phosphorylated-PI3K, phosphorylated-Akt and vascular endothelial growth factor A (VEGF-A) were all reduced in the infarcted hearts of MI mice compared to sham group, and all of these decreased expressions were restored after BPV treatment in MI mice (Fig. 5a–d). Here, AKT1 is linked to myocardial infarction.