PURPL and osteosarcoma: Among downregulated genes, there are several small nucleolar RNA host genes as well as many cancer related LncRNAs such as MINCR-MYC-induced long non-coding RNA associated with lung cancer [27], ZEB1 antisense RNA 1 associated with osteosarcoma [28] or PURPL-p53 upregulated regulator of p53 levels which suppresses p53 and promotes tumorigenicity in colorectal cancer [29].