Inhibitory effect of compound 26 against the human colon cancer HT-29, LS180, LoVo, and LoVo/DX cell lines; estrogen-receptor-positive breast cancer cells MCF-7; triple-negative breast cancer (TNBC) cells MDA-MB-231; human cervical cancer cells HeLa; human ovarian cancer cells Caov-3; human lung cancer cells A549; human liver cancer cells HepG2; human nasopharyngeal cancer cells CNE-1; human T-lymphoblastoid leukemia cells CEM-SS; human erythromyeloblastoid leukemia cells K562; and normal human embryonic kidney HEK-293 cells. The gene discussed is ESR1; the disease is malignant colon neoplasm.