BACE1 and early-onset autosomal dominant Alzheimer disease: Sakata et al. [56] synthesized a series of 2-aminochalcones (Figure 25) and tested their activity against the neurodegenerative Alzheimer’s disease markers, namely, acetylcholinesterase (AChE), β-secretase (BACE-1), and the amyloid-β (Aβ).