Identification of the BLK, HCK, FRK, ABL2, DDR1, LYN, EPHA8, FYN, LCK, and TEC kinases as potentially significant mediators of pancreatic cancer progression and fibrotic/desmoplastic development fits well into established knowledge while also advancing new avenues of drug development and discovery. The gene discussed is BLK; the disease is familial pancreatic carcinoma.