Identification of the BLK, HCK, FRK, ABL2, DDR1, LYN, EPHA8, FYN, LCK, and TEC kinases as potentially significant mediators of pancreatic cancer progression and fibrotic/desmoplastic development fits well into established knowledge while also advancing new avenues of drug development and discovery. This evidence concerns the gene FRK and familial pancreatic carcinoma.