STING1 and neoplasm: Indeed, even if APCs cannot be infected by the retargeted R-LM113 due to entry restriction, they are still able to activate their own STING by: (i) phagocyting viral particles; (ii) engulfment with fragments of dead tumor cells containing viral genomes [22]; and (iii) drawing cGAMP from infected cancer cells via gap junctions [19].