The STING pathway efficiently counteracts viral infection by both inhibiting in-cell viral replication and protecting surrounding non-infected cells from viral spread through: (i) paracrine type I IFNs secretion; (ii) cGAMP transfer via gap junctions; (iii) release of extracellular vesicles and cell debris containing activated STING and cGAMP [9,10,11,12]. Here, STING1 is linked to viral infectious disease.