ZNF35 and cancer: Unlike the human-engineered genomic variations of the T-Vec and Myb34.5 oncolytic HSVs, HF10 is a natural, spontaneously mutated HSV variant; the well-characterized mutations of HF10 and assumed resultant, potentially favorable, oncolytic activity have been assessed against many differing forms of cancer with positive results in preclinical models with and without combination therapy with chemotherapeutic agents [30].