A role for KHDRBS1 in cancer progression has been suggested by Valacca et al., who observed that KHDRBS1 regulates the transformation of epithelial cancers by up-regulating the expression of the proto-oncogene SF2/ASF, which is important for the decision of EMT vs. mesenchymal-to-epithelial transition (MET) program and a crucial event in the formation of metastasis [35]. The gene discussed is SRSF1; the disease is cancer.