Among P2YRs, P2Y1R, P2Y2R and P2Y6R support cell growth of healthy and cancer cells by activating the PI3K-AKT and ERK-MAPK pathways or by exacerbating DNA damage in tumor cells [124], thus eATP in the TME may promote tumor proliferation and support invasiveness and metastatic spreading via P2YRs. This evidence concerns the gene P2RY2 and cancer.