In short, the combination of PTT with tumor-immunotherapy almost completely inhibit tumor growth accompanied with enhanced immune responses and elevated production of various antitumor factors (TNF-α, INF-γ, IL-6, IL- 12, NO), leading not only in the suppression of primary tumors growth, but also in the hindrance of lung metastasis in CT26 tumor bearing mice. Here, IL6 is linked to neoplasm.