EZH2 and Parkinsonism: In fact, the Met-encapsulated PDA nanoparticles demonstrated excellent neuroprotective potential and anti-Parkinsonism effect through various mechanisms that are namely: the upregulation of enhancer of zeste homolog 2 (EZH2) expression, proteasomal degradation of aggregated phospho-serine 129 (pSer129) α- Syn, suppression of apoptosis and anti-inflammatory activities as well as oxidative stress reduction.