In addition to TTR's well-documented ability to bind Aβ peptides, TTR proteolytic activity has been also shown to impact on Aβ fibrillogenesis [21], neuronal-secreted Aβ degradation, and reduction of Aβ-induced toxicity in hippocampal neurons [52,68], thereby contributing to the neuroprotective effect of TTR in AD. Here, TTR is linked to Alzheimer disease.