FADS2 and type 2 diabetes mellitus: In the discovery cohort, there were 53 differentially methylated regions associated with birthweight, such as loci within Fatty Acid Desaturase 2 (FADS2) and Complexin 1 (CPLX1) genes [43], which in turn have been associated with type 2 diabetes [71] and glucose-stimulated insulin release [72], respectively.