IDO1 and melanoma: In an IDO overexpressing melanoma murine model (B16-IDO cells transplanted in C57BL/6J mice), this combined treatment [PLX647 incorporated into rodent chow (800 ppm chow) plus indoximod, either dissolved in methylcellulose and administered in drinking water, 2 mg/mL, for a total of 4.5–5.5 mL/day, or administered as implantable subcutaneous pellets, 140 mg/pellet, 14-day-release)] increased mice overall survival and sensitivity to ICIs.