By quantifying the expression of CSF-1, CSF1R, CD163 (a M2 marker) and CD8 on histological sections of human primary tumors and cutaneous metastases samples, it was demonstrated that tumor areas with high density of tumor-infiltrating CD8+ T-cells were also rich in CSF-1+ tumor cells and CSF1R+/CD163+ TAMs, while in regions where the infiltrated CD8+ T-cell population was limited, scarce M2-TAMs were revealed [94]. Here, CSF1R is linked to neoplasm.