CSF2 and neoplasm: B16F10 melanoma cells transduced with a GM-CSF expression vector (B16-GM-CSF), to obtain tumors more infiltrated by suppressive myeloid cells and less sensitive to immune checkpoint blockade, revealed a significant tumor growth inhibition when exposed to IPI-549, a selective inhibitor of the PI3K-γ subunit (15 mg/kg/day) [117].