For what concern amino acid metabolism, the pro-tumor and anti-immunity function of ARG-1, based on arginine depletion, has been assessed in C57BL/6 mice after subcutaneous inoculation of B16 murine melanoma cells (and other syngeneic murine cancer models) and administration of the small-molecule arginase inhibitor CB-1158 (also indicated as INCB001158). This evidence concerns the gene ARG1 and melanoma.