A currently still recruiting phase 1/1b clinical trial (NCT03502330) is studying the triple combination of nivolumab, cabiralizumab (a humanized mAb directed against CSF1R) and APX005M (a humanized agonistic mAb that binds to CD40 and acts as an immuno-activating agent by triggering the release of IFN-γ), in advanced melanoma, NSCLC and renal cell carcinoma. The gene discussed is IFNG; the disease is melanoma.