During melanoma progression, the stimulation of their receptor (IL-1R) in M2-TAMs was found to up-regulate the expression of the DNA methylcytosine dioxygenase Ten-Eleven-Translocation-2 (Tet2), a well-known tumor suppressor exerting immunosuppressive functions in hematopoietic malignancies. Here, TET2 is linked to neoplasm.