VSIR and neoplasm: Other immune checkpoint ligands expressed by TAMs, with a potential direct suppressive effect on tumor-infiltrating T-cells, are B7-H4 (also known as B7x, B7S1 or VTCN1) and V-domain Ig-containing suppressor of T-cell activation (VISTA, also known as PD-1H, B7-H5, DD1α) [58,59,60].