The membrane form of this receptor is activated by some members of the VEGF family of growth factors (i.e., VEGF-A, VEGF-B and PlGF) and is known to play an important role in melanoma invasiveness, vasculogenic mimicry, neo-angiogenesis as well as in the mobilization of myeloid progenitors from the bone marrow to the tumor site [121,122]. The gene discussed is PGF; the disease is neoplasm.