Up-regulated during T-cell activation, the immune checkpoint molecules, such as programmed cell death 1 (PD-1), programmed cell death protein ligand 1 (PD-L1) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4), prevent an excessive immune response, potentially leading to tissue damage or to the establishment of an autoimmune disease. Here, CTLA4 is linked to autoimmune disease.