CSF2 and cancer: The only therapeutic cancer vaccine that has been approved by the FDA is Sipuleucel-T, an autologous active cellular immunotherapy that consists of activated monocytes as APCs presenting a recombinant fusion protein of prostatic acid phosphatase fused to immunostimulant granulocyte-macrophage colony-stimulating factor (GM-CSF) against metastatic castrate-resistant prostate cancer, demonstrating improvement in overall survival [53].