Although reported to be associated with AD pathogenesis dependent on Aβ burden, some vascular risk factors of the APOE ε4 genotype, higher systolic blood pressure etc. did not substantially increase the predictive performance in MCI with normal CSF Aβ; Aβ42 individually and in combination with t-tau and p-tau improved the prediction of progression to dementia [87]. The gene discussed is APOE; the disease is Alzheimer disease.