Release of IL-8, CCL2/MCP1 (monocyte chemoattractant protein-1) and tissue inhibitor of metalloproteinase 2 (TIMP-2) by fibroblasts when co-cultured with melanoma cells has also been implicated in the angiogenic process indicating that recruitment of microvascular endothelial cells depends on the synergic melanoma-fibroblast network [80]. The gene discussed is CCL2; the disease is melanoma.