In melanoma, epigenetic regulation of Wnt antagonists such as Dickkopf proteins (DKKs), Wnt inhibitor factor-1 (WIF1) and soluble frizzled-related protein-2 sFRP2 contributes substantially to cell-autonomous activation of Wnt/β-catenin signaling [113,114]. This evidence concerns the gene SFRP2 and melanoma.