Shao and co-workers reported that the expression of Wnt-induced secreted protein-1 (WISP-1), a β-catenin target gene, is almost undetectable in areas with melanoma and in the surrounding tissue, whereas strong expression has been observed in non-activated fibroblasts of uninvolved skin [158] indicating a negative correlation between WISP-1 expression and a permissive tumor microenvironment. This evidence concerns the gene CCN4 and neoplasm.