Modification of Wnt pathway modulators in melanoma cells, including Wnt5a [128,144,145], Wnt7b, Wnt10b [146], Frizzled-3 (FZD3) [130] and DKKs [113] has been largely investigated as a cell autonomous mechanism responsible of signaling activation in tumor cells. The gene discussed is FZD3; the disease is neoplasm.