This pathway is thought to be central to uveal melanomagenesis as YAP is hyperactive in uveal melanoma cells and mediates the oncogenic effect of guanine nucleotide binding protein (G protein) q polypeptide (GNAQ), or G protein α 11 (GNA11) mutations, which occur in approximately 80% of these type of melanoma [170,171]. This evidence concerns the gene GNAQ and uveal melanoma.