Considering these approaches, our results suggest that in the case of CRC patients developing cachexia, the high bioaccessibility and permeability of saponins from FE at the intestinal level (small intestine) would allow this extract to be a good candidate to promote anabolic effects systemically, taking into account the relevant results observed for SREBF1, FASN, SCD, and LDLR, among others, for this extract. Here, LDLR is linked to colorectal carcinoma.