On the other hand, in the case of CRC patients where lipid metabolism-related genes associated to progression and metastasis such as SREBF1, FASN, ABCA1, and the ACSL/SCD axis, among others, are overexpressed, it should be desirable to develop formulas to deliver FE to the colon in order to be metabolized by the colonic microbiota to release the aglycone sapogenins. This evidence concerns the gene ABCA1 and colorectal carcinoma.