On the other hand, HFE inhibited lipid metabolism targets, including SREBF1, FASN, SCD, SREBF2, HMGCR, LDLR, FABP1, ABCA1, and the metabolic axis ACSL/SCD, all of which have been implicated in poorer prognosis in CRC [3]. This evidence concerns the gene SREBF2 and colorectal carcinoma.