NFE2L2 and Autoimmunity: The increased oxidative stress in tissues of subjects or model organisms with autoimmune diseases [24] along with the systemic inflammation inherent in autoimmunity has made the Nrf2 pathway an attractive potential target, not only because of its antioxidant cytoprotective role but also because activation of Nrf2 can block inflammatory responses at the transcriptional level by repressing upregulation of Il-6 and Il-1β in macrophages [25].