Indeed, within the CORDIOPREV study, the long-term intake of a Med diet, rich in olive oil, or a LF diet similarly improved insulin sensitivity and beta-cell function [7] and, therefore, the increase in the expression of specific splicing factors found herein under both diets, and their inverse correlation with insulin resistance indexes, strongly suggest that the molecular changes might be related to the beneficial consequence of consumption of a healthy diet. Here, INS is linked to Insulin resistance.