In summary, we believe Ex training may confer attenuating the CRS because changes in these proinflammatory cytokines may be modulated by anti-inflammatory cytokines, such as IL-1ra, IL-6, and IL-10, and cytokine inhibitors, such as cortisol, prostaglandin E2, and soluble receptors against TNF and IL-2 [26,30]. Here, TNF is linked to congenital rubella syndrome.