Results are conflicting results with most of the studies showed LSPTX is inferior compared to the other two approaches.<h4>Discussion</h4>Therefore, given the current body of evidence, we consider that subtotal or total parathyroidectomy is still the preferred surgical approach for the treatment of PHPT in MEN1.<h4>Conclusion</h4>Further studies are still needed to see whether LSPTX is comparable to SPTX or TPTX in regards to persistent and recurrent hyperparathyroidism if the conditions are met. The gene discussed is MEN1; the disease is hyperparathyroidism.