MOG and experimental autoimmune encephalomyelitis: Extensive analyses have been carried out in animal models to investigate the contribution of MOG-specific antibodies to the pathogenesis of disease.13, 14, 15, 16, 17, 18 Studies in rodent models have demonstrated that this protein is a target of autoreactive B and T cell responses that result in experimental autoimmune encephalomyelitis (EAE) and neuromyelitis optica.13