MOG and myeloid sarcoma: ,12,21 Further, reports that multiple sclerosis (MS) patient-derived antibodies specific for native MOG (human and rodent) can exacerbate EAE in rodents,17,22 combined with histopathological analyses demonstrating antibody and complement deposits in the CNS for over 50% of MS patients,23 indicate that such antibodies can also contribute to pathology in this potentially devastating disease.