,14,18,19 In addition, the implementation of assays for the detection of MOG-specific antibodies that recognize MOG in its native conformation2,9,19,20 has indicated the involvement of MOG-specific antibodies in the pathogenesis of multiple demyelinating diseases that include acute disseminated encephalomyelitis (ADEM), anti-aquaporin-4-antibody-seronegative neuromyelitis optica spectrum disorder (NMOSD), myelitis, optic neuritis, and brainstem encephalitis.2 This evidence concerns the gene AQP4 and acute disseminated encephalomyelitis.