Taking into consideration the selectivity of TH5487 for arresting cancer cell proliferation (Figure 3), and that amplification and/or upregulation MCMs members have been identified as biomarkers of progression and negative outcome in several cancer types (68), including OGG1 inhibition in clinical prevention strategies for cancer treatment, based on the MCMs expression status, could be of benefit. The gene discussed is OGG1; the disease is cancer.