Nonetheless, the adjusted HR of RCC was still higher in the alpha-1 blocker–exposed cohort, regardless of whether the patients were diagnosed as having hypertension (adjusted HR, 1.53; 95% CI, 1.21−1.93; P < .001 for the presence of hypertension; odds ratio, 1.06; 95% CI, 1.04−2.45; P < .05 for the absence of hypertension). Here, PSMA6 is linked to Hypertension.