PSMA6 and cancer: In a sampling cohort of approximately 2.3 million participants enrolling between January 1, 2000 and December 31, 2010, a total of 582,941 patients were identified as new alpha-1 blocker users and classified as exposed after exclusion of those who were prescribed alpha-1 blockers in 2000, diagnosed as having RCC and other cancers prior to index day, and aged > 90 years.