MAPK8 and neoplasm: Following activation of JNK/c-Jun signal pathway, there are generally two ways to induce the apoptosis of tumor cells: increasing the expression of pro-apoptotic proteins, such as p53 and Bad, and inducing alterations within mitochondria, including activation of the binding of related proteins like Bax and cytochrome C to subsequently act on Caspase3 to cause apoptosis by binding with apoptosis-related substrates.