Previous studies have found either no interaction38 between LTPA and APOE status on cognition or that APOE ε4 carriers benefitted more from the exercise intervention than APOE ε4 noncarriers.39 Thus, the current study adds to the literature suggesting that LTPA might be an important intervention target for brain health and dementia prevention among APOE ε4 carriers. This evidence concerns the gene APOE and dementia.