Interestingly, it has been shown that Δ9-THC as well as synthetic cannabinoid agonists upregulate Trib3 expression (Blázquez et al., 2006; Carracedo et al., 2006; Salazar et al., 2013; Vara et al., 2011) to engage apoptosis in variable cancer models. Here, TRIB3 is linked to cancer.