Specifically in the liver, Chikka and colleagues suggest that CHOP is a suppressor of key regulators of lipid metabolism like Cebpa, Ppara, and Srebf1 (Chikka et al., 2013), and demonstrate that CHOP-deficient mice tend to develop hepatic steatosis in response to bortezomib-induced ER stress. Here, SREBF1 is linked to Hepatic steatosis.