Specifically in the liver, Chikka and colleagues suggest that CHOP is a suppressor of key regulators of lipid metabolism like Cebpa, Ppara, and Srebf1 (Chikka et al., 2013), and demonstrate that CHOP-deficient mice tend to develop hepatic steatosis in response to bortezomib-induced ER stress. This evidence concerns the gene DDIT3 and Hepatic steatosis.