Previously, researches showed Sophoridine could inhibit colorectal carcinoma, gastric cancer, glioma, lung cancer, medulloblastoma, pancreatic cancer through inhibiting the activity of ubiquitin‐proteasome, remodelling tumour‐associated macrophages polarization via TLR4 pathway, up‐regulating caspases and PARP expression to induce cell apoptosis, activating the p53 and Hippo signalling pathways, and inducing cell cycle arrest in G0/G1 phase or S phase arrest.13, 19, 20, 21, 22. The gene discussed is TLR4; the disease is colorectal carcinoma.