NKX6-1 and Parkinson disease: More recently, Soldner and colleagues used CRISPR/Cas9-based gene editing to uncover the effect of a PD-related single-nucleotide polymorphism in the SNCA locus by generating a collection of isogenic lines, identifying a common PD-associated risk variant in a non-coding distal enhancer element that regulates the expression of α-syn by differential binding of two brain-specific transcription factors (EMX2 and NKX6-1) [37].