Similar results have been reported by Yu et al., where inhibition of p53 in subarachnoid hemorrhage (SAH) mice led to decreased levels of miR-22 and upregulation of Cyr61, whereas knock down of p53 in HEB cells (human normal glial cell line) suppressed the expression of miR-22 [25]. The gene discussed is TP53; the disease is subarachnoid hemorrhage.