HPGD and breast cancer: More recently, data mining from publicly available breast cancer gene expression datasets from the Cancer Genome Atlas (TCGA, https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga) and Oncomine (https://www.oncomine.org/), revealed decreased expression of HPGD mRNA in breast cancer samples compared with normal, healthy breast tissue [19].