Martinac et al. (2001) found that degrading astrocytes were inversely correlated with cerebral blood flow in FTD. However, more importantly, astrocytes derived from induced pluripotent stem cells of patients with mutations in MAPT were found to demonstrate increased vulnerability to oxidative stress and exhibit disease-associated gene-expression changes (Hallmann et al., 2017). This evidence concerns the gene MAPT and frontotemporal dementia.