Notably, the KEGG pathway for ALS, which features only 53 genes, did not reach statistical significance after FDR correction in any of the three groups (OR = 2.12, P = 0.0198, PFDR=0.59 in the GRN list, P > 0.05 in the MAPT and C9orf72 lists). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.