Consistent with previous results, we observed strong, obesity‐induced downregulation of CYP2R1 expression in mouse liver.(16, 17) Although the HFD‐feeding induced more severe liver steatosis in the male mice than the female mice, it had a similar effect on CYP2R1 expression. Here, CYP2R1 is linked to obesity due to melanocortin 4 receptor deficiency.