The study also helps in finding common molecular trajectories of nSARS-CoV-2 with clotting, pulmonary embolism, pulmonary edema, and systematic inflammation which shows fibrinolysis as a major pathway that increases the D-dimers in the nSARS-CoV-2 infection and cytokines TGF-β and TNF-α as major regulators of fibrinolysis controlling proteins PAI-1 and plasminogen activators. The gene discussed is SERPINE1; the disease is pulmonary embolism.