MUC5B and cancer: Priming with Ad5 encoding a cancer antigen, followed by boosting with ORV vectors, such as MG1 or VSV, expressing the same antigen, induces strong antigen-specific responses, providing survival benefit in various tumor models.11, 12, 13, 14, 15 Therefore, we tested the ability of the combination aDEC205-OVA prime and MG1-OVA boost in the generation of a SIINFEKL-specific T cell response.