JAK1, JAK2 and JAK3 were on the prediction list (Table S4†), none of which were previously reported to be the target of cladribine, to the best of our knowledge albeit there are studies indicating the involvement STAT protein phosphorylation with cladribine treatment in multiple myeloma cells.52,53 Since JAK/STAT signaling was involved in both lymphoblastic diseases and immune response and since it has been previously reported that it might be involved in cladribine action, we pursued to validate cladribine and JAK/STAT DEEPScreen prediction in vitro. Here, JAK3 is linked to plasma cell myeloma.