STAT3 and neoplasm: The Janus kinase/signaling transducers and activators of the transcription (JAK/STAT) pathway, activated by cytokines and growth factors, play important roles in the immune system, cell survival, cell proliferation and cell death, and tumor development.54 The signal transducer and activator of transcription 3 (STAT3) is one of the downstream effectors of JAK proteins.