Research found that CALR silencing prevented Epibrassinolide (EBR, a member of brassinostreoids plant hormones)-induced UPR and apoptosis in colon cancer cells, indicating that CALR inhibited EBR induced apoptosis through activating ER stress (Obakan-Yerlikaya et al. 2017). Here, CALR is linked to malignant colon neoplasm.