BRAF and neoplasm: The genomic landscapes of EOCRC and late-age-onset CRC (LOCRC) were characterised recently, and while many similarities were noted overall, marked differences were noted in rates of specific mutations when microsatellite stable (MSS) and high-frequency microsatellite instability (MSI-H) subgroups were analysed separately.11 Specifically, the most commonly mutated genes in MSS tumours, such as APC, KRAS, BRAF, PIK3CA and AMER1, were less frequent among EOCRC compared to LOCRC.11