CD8A and neoplasm: Inclusion of adjunct tools, such as immunoscore,36 a robust and validated test of the host immune reaction measuring CD3+ and CD8+ T-cell densities within the tumour and/or detection of ctDNA may be considered for determination of the risk of recurrence.37,38 To our knowledge, this is the first study determining the influence of RAS mutations on overall survival from the perspective of the age of onset in RAS-driven colorectal cancer liver resections.