WFDC2 and endometriosis: Our results of CA125 (82.4%) and HE4 (62.6%) sensitivities, however, were different from the above results, which may be caused by different disease-entry criteria—as CA125 and HE4 are also upregulated in many other diseases, including uterine fibroids, diverticulitis, endometriosis, liver cirrhosis, normal menstruation, and pregnancy26–28.