In routine clinical practice, BC can be classified into prognostic and predictive subtypes based on the immunohistochemical (IHC) expression of the estrogen receptor (ER), the progesterone receptor (PgR) and the human epidermal growth factor receptor type 2 (HER2), with or without in situ hybridization of the latter, in equivocal 2 + tests2. This evidence concerns the gene ERBB2 and breast cancer.