To assess whether L. lactis NCDO2118 FnBPA+ (pXYCYT:Hsp65) can modulate the cytokine levels in chronic colitis, the levels of IFN-γ, IL-12, IL-6, IL-13, IL-17, TGF-β and IL-10 in colonic tissues were measured. The gene discussed is HSPD1; the disease is Chronic colitis.