According to the studies of Wang et al. and Han et al25,36, miR-34a-5p could inhibit proliferation, migration, invasion and epithelial-mesenchymal transition in Esophageal Squamous Cell Carcinoma by targeting lymphoid enhancer-binding factor 1 and suppressing the Hippo-YAP1/TAZ signaling pathway, and The lncRNA CRNDE could promote colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling. Here, LEF1 is linked to colorectal cancer.