For instance, gene rearrangements affecting core binding factor (CBF) complex, RUNX1-RUNX1T1/t(8;21) or CBFB-MYH11/inv(16) are found in about 15% of AML patients (hereafter referred to as t(8;21) and inv(16) AML, respectively)9. Here, RUNX1T1 is linked to acute myeloid leukemia.