Intriguingly, HCT-116 colon cancer cell line, which was reported as not responder to SB treatment, as suggested by the lack of induction of ALP activity25, still demonstrated a slight increase in E-Cadherin, while ZO-1 pattern was similar to HT-29 cells (Supplementary Fig. S5). The gene discussed is TJP1; the disease is colonic neoplasm.